Infections transmitted by transplantation.

نویسندگان

  • Michele I Morris
  • Staci A Fischer
  • Michael G Ison
چکیده

Infections are frequently transmitted through solid-organ and, to a lesser extent, stem cell transplantation. There are 2 major types of donor-derived infections that are transmitted: those that would be expected secondary to donor and recipient screening (ie, transmission of cytomegalovirus, Epstein-Barr virus, or toxoplasmosis from a seropositive donor to a seronegative recipient) and those that are unexpected despite routine donor screening (ie, human immunodeficiency virus and hepatitis C virus transmitted from a seronegative donor). Expected transmissions occur frequently and screening and prophylaxis strategies are applied to at-risk individuals in nearly all transplant centers globally. Several high profile donor-derived infectious disease transmissions have been recognized; these reports have raised awareness of this rare complication of transplantation. Issues related to the epidemiology of, screening for, and management of proven or probable donor-derived infections are reviewed in this article.

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عنوان ژورنال:
  • Infectious disease clinics of North America

دوره 24 2  شماره 

صفحات  -

تاریخ انتشار 2010